DNA Gluten Panel (DQ2 & DQ8)
Indications
- Coeliac disease assessment: Determining whether genetic susceptibility is present.
- Persistent gastrointestinal symptoms: Bloating, diarrhoea, abdominal discomfort or unexplained digestive disturbance.
- Unexplained nutritional deficiencies: Iron deficiency, low B12, folate deficiency or impaired absorption of fat-soluble vitamins.
- Family history of coeliac disease: First-degree relatives diagnosed with coeliac disease or gluten-related disorders.
- Autoimmune conditions: Thyroid disease, type 1 diabetes or other immune-mediated health concerns.
- Unexplained fatigue or weight loss: Ongoing symptoms without a clear gastrointestinal diagnosis.
- Bone health concerns: Reduced bone density or history of fractures linked to possible malabsorption.
- Dermatological symptoms: Persistent rashes or skin conditions suggestive of gluten-related immune responses.
- Fertility concerns: Unexplained subfertility or recurrent pregnancy difficulties in the context of possible malabsorption.
Overview
Traditional approaches to understanding personal health often involve antibody blood tests or invasive procedures, but these methods might not always provide clear information, especially for younger individuals. An alternative perspective involves exploring genetic information through DNA Gluten Panel (DQ2 & DQ8) testing. This approach focuses on inherited genetic markers that relate to immune system function and can offer additional insights beyond conventional methods.
The human immune system relies on HLA (Human Leukocyte Antigen) gene variants to distinguish between the body’s own cells and external challenges. Variations in these HLA genes create different haplotypes, with HLA-DQ2 and HLA-DQ8 being of particular interest. Many people carry these haplotypes without any health issues, but their presence provides valuable information about how the immune system is naturally wired, which can be relevant for understanding susceptibility to certain responses.
While having the HLA-DQ2 or HLA-DQ8 haplotype is not a guarantee of any health condition developing, the DNA Gluten Panel (DQ2 & DQ8) testing can help clarify an individual’s genetic predisposition. This can serve as a useful tool in combination with other personal health assessments, aiding people who seek to explore their wellness, nutritional choices and digestive comfort from a genetic perspective. Understanding these genetic markers can help guide discussions about lifestyle and health optimisation.
DNA Gluten Panel (DQ2 & DQ8) is intended for informational, educational, wellness and/or research purposes only. It is not intended for use in medical diagnosis, disease screening or clinical decision-making. DNA Gluten Panel (DQ2 & DQ8) is not a replacement for clinical laboratory testing and does not provide medical diagnoses. This content is intended for general information within the EU market and should not be interpreted as a regulated in-vitro diagnostic claim.
Research
Research
• Babron, M., Nilsson, S., Adamovic, S., Naluai, Å T., Wahlström, J., Ascher, H., . . . Clerget-Darpoux, F. (2003). Meta and pooled analysis of European coeliac disease data. European Journal of Human Genetics, 11(11), 828-834. DOI: 10.1038/sj.ejhg.5201051
• Heel, D. A., Franke, L., Hunt, K. A., Gwilliam, R., Zhernakova, A., Inouye, M., . . . Wijmenga, C. (2007). A genome-wide association study for celiac disease identifies risk variants in the region harboring IL2 and IL21. Nature Genetics, 39(7), 827-829. DOI: 10.1038/ng2058
• Hunt, K. A., Zhernakova, A., Turner, G., Heap, G. A., Franke, L., Bruinenberg, M., . . . Heel, D. A. (2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nature Genetics, 40(4), 395-402. DOI: 10.1038/ng.102
• Monsuur, A. J., Bakker, P. I., Zhernakova, A., Pinto, D., Verduijn, W., Romanos, J., . . . Wijmenga, C. (2008). Effective Detection of Human Leukocyte Antigen Risk Alleles in Celiac Disease Using Tag Single Nucleotide Polymorphisms. PLoS ONE, 3(5). DOI: 10.1371/journal.pone.000227
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