NordivVMS

DNA Gut

Bloodspot

21 Days

Indications

Digestive wellness: Addressing bloating, abdominal discomfort, diarrhoea, constipation, or bowel habit changes.
Gut regulation support: Managing IBS patterns, dysbiosis, food sensitivities, or post-infectious changes.
Inflammatory/immune health: Considering history of IBD, coeliac disease, or immune-related gut symptoms.
Food tolerance assessment: Evaluating responses to gluten, lactose, starches, or fibre.
Gut-brain balance: Linking genetic influences on digestion to stress, mood, cognitive fatigue, or sleep issues.
Barrier function support: Supportive management of influences for recurrent infections, inflammation, or intestinal permeability.
Preventative gut health: Tailored strategies for microbiome resilience and GI maintenance.

Overview

DNA Gut evaluates genetic variations linked to key biological pathways that influence gut wellbeing and digestive balance. This includes analysis of 26 genetic variants across 18 genes associated with factors such as gut motility, microbial presence, metabolite profiles, barrier function, and immune activity. Understanding these genetic influences offers insight into personal responses to environmental and lifestyle factors affecting gastrointestinal comfort and resilience. By considering these elements, DNA Gut supports greater awareness of individual digestive characteristics and provides a foundation for nutritional and lifestyle adjustments aimed at promoting digestive harmony.

The evaluation covers multiple facets related to gut function, including transit time, microbial diversity, metabolite production, integrity of the gut barrier, and immune interactions. These aspects collectively contribute to maintaining a balanced gut environment and overall digestive wellbeing. DNA Gut integrates this genetic information to offer perspectives on how variations may relate to digestive function and microbial balance, contributing to more informed considerations of diet and wellness. The test presents an opportunity to explore personal genomic data in relation to digestive health without implying clinical diagnostic conclusions.

Downloads

Collection instructions

English

Sample Report

English

German

Research

Research
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Wacklin P, Mäkivuokko H, Alakulppi N, Nikkilä J, Tenkanen H, Räbinä J, et al. Secretor Genotype (FUT2 gene) Is Strongly Associated with the Composition of Bifidobacteria in the Human Intestine. PLoS ONE. 2011 May 19;6(5):e20113.
Mogensen TH. Pathogen Recognition and Inflammatory Signaling in Innate Immune Defenses. Clin Microbiol Rev. 2009 Apr;22(2):240–73.
Hold GL, Berry S, Saunders KA, Drew J, Mayer C, Brookes H, et al. The TLR4 D299G and T399I SNPs Are Constitutively Active to Up-Regulate Expression of Trif-Dependent Genes. PLoS ONE. 2014 Nov 3;9(11):e111460.
Salem M, Ammitzboell M, Nys K, Seidelin JB, Nielsen OH. ATG16L1: A multifunctional susceptibility factor in Crohn disease. Autophagy. 2015 Apr 23;11(4):585.
Jauregi-Miguel A, Santin I, Garcia-Etxebarria K, Olazagoitia-Garmendia A, Romero-Garmendia I, Sebastian-delaCruz M, et al. MAGI2 Gene Region and Celiac Disease. Front Nutr. 2019 Dec 19;6:187.
Kafentzi T, Tsounis EP, Tourkochristou E, Avramopoulou E, Aggeletopoulou I, Geramoutsos G, et al. Genetic Polymorphisms (ApaI, FokI, BsmI, and TaqI) of the Vitamin D Receptor (VDR) Influence the Natural History and Phenotype of Crohn’s Disease. Int J Mol Sci. 2025 Jan;26(5):1848.
Gross C, Krishnan AV, Malloy PJ, Eccleshall TR, Zhao XY, Feldman D. The Vitamin D Receptor Gene Start Codon Polymorphism: A Functional Analysis of FokI Variants. J Bone Miner Res. 1998;13(11):1691–9.
Paz JLP, Silvestre M do PSCA, Moura LS, Furlaneto IP, Rodrigues YC, Lima KVB, et al. Association of the polymorphism of the vitamin D receptor gene (VDR) with the risk of leprosy in the Brazilian Amazon. Biosci Rep. 2021 Jul 6;41(7):BSR20204102.
Su Y, Zhao H. Predisposition of Inflammatory Bowel Disease Is Influenced by IL-8, IL-10, and IL-18 Polymorphisms: A Meta-Analysis. Int Arch Allergy Immunol. 2020;181(10):799–806.
Zhu SW, Liu ZJ, Sun QH, Duan LP. Effect of the interleukin 10 polymorphisms on interleukin 10 production and visceral hypersensitivity in Chinese patients with diarrhea-predominant irritable bowel syndrome. Chin Med J (Engl). 2019 Jul 5;132(13):1524.
Meglio PD, Cesare AD, Laggner U, Chu CC, Napolitano L, Villanova F, et al. The IL23R R381Q Gene Variant Protects against Immune-Mediated Diseases by Impairing IL-23-Induced Th17 Effector Response in Humans. PLOS ONE. 2011 Feb 22;6(2):e17160.
Perše M, Unkovic A, Perše M, Unkovic A. The Role of TNF in the Pathogenesis of Inflammatory Bowel Disease. In: Biological Therapy for Inflammatory Bowel Disease [Internet].
Zhao T, Zhang Y, Lee J, Starkweather AR, Young EE, Cong X. The Associations of Single Nucleotide Polymorphisms with Risk and Symptoms of Irritable Bowel Syndrome. J Pers Med. 2022 Jan 21;12(2):142.
Eam F, et al. SLC39A8 missense variant is associated with Crohn’s disease but does not have a major impact on gut microbiome composition in healthy subjects. PloS One [Internet]. 2019 Jan 31 [cited 2025 Feb 20];14(1). Available from: https://pubmed.ncbi.nlm.nih.gov/30703110/.
Pereira C, Grácio D, Teixeira JP, Magro F. Oxidative Stress and DNA Damage: Implications in Inflammatory Bowel Disease. Inflamm Bowel Dis. 2015 Oct;21(10):2403–17.
Kapeller J, Houghton LA, Mönnikes H, Walstab J, Möller D, Bönisch H, et al. First evidence for an association of a functional variant in the microRNA-510 target site of the serotonin receptor-type 3E gene with diarrhea predominant irritable bowel syndrome. Hum Mol Genet. 2008 Oct 1;17(19):2967–77.
Gujral N. Celiac disease: Prevalence, diagnosis, pathogenesis and treatment. World J Gastroenterol. 2012;18(42):6036.
Gromova LV, Fetissov SO, Gruzdkov AA. Mechanisms of Glucose Absorption in the Small Intestine in Health and Metabolic Diseases and Their Role in Appetite Regulation. Nutrients. 2021 Jul 20;13(7):2474.
Porzi M, Burton-Pimentel KJ, Walther B, Vergères G. Development of Personalized Nutrition: Applications in Lactose Intolerance Diagnosis and Management. Nutrients. 2021 Apr 29;13(5).